Sign Out
Pharmacology: Pharmacodynamics: Antazoline hydrochloride is an H1 receptor antagonist which also possesses some local anaesthetic properties. It can relieve any symptoms of allergic conjunctivitis mediated by histamine.
Tetrahydrozoline hydrohloride, a vasoconstrictor, is structurally and pharmacologically closely related to Naphazoline. It is a conjunctival congestion by stimulates α-adrenergic receptors of the sympathetic nervous system.
Antazoline hydrochloride and in combination with the vasoconctrictor was effective in the treatment of allergic conjunctivitis.
Hydroxypropyl methylcellulose have been added to increase the viscosity of eye drop to reduce the lacrimal clearance of ophthalmic solution. It can prolong the ocular contact time of Antazoline hydrochloride and Tetrayzoline hydrochloride.
Pharmacokinetics: The pharmacokinetic of Antazoline hydrochloride is incomplete data available. However, has a short duration of activity.
Tetrahydrozoline hydrochloride is a local vasoconstriction usually occurs within a few minutes and may persist for 4-8 hours.
